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KMID : 1007520140230020555
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Food Science and Biotechnology
2014 Volume.23 No. 2 p.555 ~ p.560
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Whitening Effects of 4-Hydroxyphenethyl Alcohol Isolated from Water Boiled with Hizikia fusiformis
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Jang Mi-Soon
Park Hee-Yeon
Nam Ki-Ho
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Abstract
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Isolation of phenolic compounds from water boiled with Hizikia fusiformis and purificartrion of the extracts from solvent fractions was achieved using column chromatography. The simple phenolic compound, 4- hydroxyphenethyl alcohol (4-HPEA) with an elemental composition C8H10O2 was identified on the basis of spectroscopic data. The whitening effects of 4-HPEA, inhibitory activity against mushroom tyrosinase, and inhibitory activity against melanin production in B16 melanoma cells were evaluated using an in vitro assay system. The whitening effect of 4-HPEA was also measured using a colorimeter and visual assessment of UVB induced hyperpigmentation of brown guinea pig skin. Topical application of 4-HPEA promoted depigmentation of UVBinduced hyperpigmented spots. 4-HPEA has a potential for use as a safe and effective ingredient for whitening in cosmetic and medical applications.
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KEYWORD
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Hizikia fusiformis, 4-hydroxyphenethyl alcohol, whitening effect, brown guinea pig, tyrosinase
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